DDO-6079
DDO-6079 is a potent CDC37 inhibitor. DDO-6079 inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone complex by binding to an allosteric site on CDC37. DDO-6079 decreases the thermostability of CDK6[1].
Product Specifications
CAS Number
2648334-53-4
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(Cl)=CC=C1O)NC2=CC(OC3=CC=CC=C3)=NC=C2
Molecular Formula
C18H13ClN2O3
Molecular Weight
340.76
References & Citations
[1]Zhang L, et al. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDC
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1610536 100 µL
Phospho-FOXO1 + FOXO3 + FOXO4 (phospho T24 + T32) Rabbit Polyclonal Antibody (BF405)
Sign In for Pricing
View Details 