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DDO-6079

DDO-6079 is a potent CDC37 inhibitor. DDO-6079 inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone complex by binding to an allosteric site on CDC37. DDO-6079 decreases the thermostability of CDK6[1].

Product Specifications

CAS Number

2648334-53-4

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Concentration

10mM

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(Cl)=CC=C1O)NC2=CC(OC3=CC=CC=C3)=NC=C2

Molecular Formula

C18H13ClN2O3

Molecular Weight

340.76

References & Citations

[1]Zhang L, et al. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDC

Available Sizes

Frequently Asked Questions

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