SIRT1-IN-4

SIRT1-IN-4 (Compound 8c) is a SIRT1 inhibitor, with an IC50 of 10.04 μM. SIRT1-IN-4 can be used for the research of cancer[1].

Product Specifications

CAS Number

[445405-18-5]

UNSPSC

12352005

Target

Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC(COC2=CC=C(/C=C3C(OC(C4=CC=CC=C4)OC\3=O)=O)C=C2)=C1)O

Molecular Formula

C25H18O7

Molecular Weight

430.41

References & Citations

[1]Li C, et al. Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors. ACS Med Chem Lett. 2021 Mar 1;12 (3) :397-403.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1

Available Sizes

Curated Selection

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