SIRT1-IN-4
SIRT1-IN-4 (Compound 8c) is a SIRT1 inhibitor, with an IC50 of 10.04 μM. SIRT1-IN-4 can be used for the research of cancer[1].
Product Specifications
CAS Number
[445405-18-5]
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC(COC2=CC=C(/C=C3C(OC(C4=CC=CC=C4)OC\3=O)=O)C=C2)=C1)O
Molecular Formula
C25H18O7
Molecular Weight
430.41
References & Citations
[1]Li C, et al. Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors. ACS Med Chem Lett. 2021 Mar 1;12 (3) :397-403.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1
Available Sizes
Curated Selection
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