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APOL1-IN-2

APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 (APOL1) . APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC50 of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC50 of 2.24, 6.03 and 3.72 nM, respectively[1].

Product Specifications

CAS Number

[2956781-84-1]

UNSPSC

12352005

Target

Apolipoprotein

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(N1[C@@H]2C[C@](C)(O)C2)N(CO)C3=C1C(C(F)(F)F)=CC(OCCN(CC4)CCC4(C(N5)=O)C6=C5C=CC(Cl)=C6)=C3

Molecular Formula

C28H30ClF3N4O5

Molecular Weight

595.01

References & Citations

[1]Lee PST, et al., APOL1 inhibitors and methods of use. US11976067B2

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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