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CDK2 degrader 5

CDK2 degrader 5 (compound 12) is a degrader for CDK2, with the Dmax of >50% and ≤80% in HiBiT Assay. CDK2 degrader 5 plays an important role in cancer research[1].

Product Specifications

CAS Number

2923574-11-0

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)OCC4=CC=CC(C5=CC=CC=C5)=C4C

Molecular Formula

C29H27N3O5

Molecular Weight

497.54

References & Citations

[1]Monte Rosa Therapeutics, Inc. Preparation of 3- (6-substituted-1-oxoisoindolin-2-yl) piperidine-2,6-dione derivatives that mediate the degradation of cyclin-dependent kinase (CDK2) and are useful in the treatment of various disorders, such as cancer. World Intellectual Property Organization, WO2023069700 A1 2023-04-27

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK2

Available Sizes

Frequently Asked Questions

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