GR–14-3-3 stabilizer-1
GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3[1].
Product Specifications
CAS Number
[271798-59-5]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Purity
99.61
Solubility
DMSO : 71.43 mg/mL (ultrasonic)
Smiles
O=C1NN=C(CSC2=CC=C(C=C2)Cl)N1C3=CC=CC=C3
Molecular Formula
C15H12ClN3OS
Molecular Weight
317.79
References & Citations
[1]Perry M, et al. Rational discovery of molecular glues for the glucocorticoid receptor–14-3-3 protein-protein interaction starting with application of traditional hit-finding methods[J]. 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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