MCI-INI-3
MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3 (with a Ki value of 0.55 μM for ALDH1A3 and a Ki value of 78.2 μM for ALDH1A1) . MCIINI-3 inhibits the biosynthesis of retinoic acid and reduces the viability of GSC-83 and GSC-326 glioblastoma cells[1].
Product Specifications
CAS Number
[1011366-31-6]
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.23
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
Molecular Formula
C21H15N3O4
Molecular Weight
373.36
References & Citations
[1]Jianfeng Li, et al. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Commun Biol. 2021 Dec 21;4 (1) :1420.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Available Sizes
Curated Selection
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