Tubulin inhibitor 49 (hydrobromide)
Tubulin inhibitor 49 (Compound 18) hydrobromide is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 hydrobromide disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell) . Tubulin inhibitor 49 hydrobromide can be used in the research of cervical cancer[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Purity
99.12
Smiles
O=C(C)NC1=CC=C(C2=CSC(NC3=CC=CC(C(F)(F)F)=C3)=N2)C=C1.Br
Molecular Formula
C18H15BrF3N3OS
Molecular Weight
458.30
References & Citations
[1]Mühlethaler T, et al., Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew Chem Int Ed Engl. 2022 Jun 20;61 (25) :e202204052.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7196030 Inquire
Rabbit anti-Oryza sativa subsp. japonica (Rice) Os06g0717400 Polyclonal Antibody
Sign In for Pricing
View Details 
CTSJ-2068M 50 µg
Recombinant Mouse CTSJ Protein, His (Fc)-Avi-tagged
Sign In for Pricing
View Details