Tubulin inhibitor 49 (hydrobromide)

Tubulin inhibitor 49 (Compound 18) hydrobromide is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 hydrobromide disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell) . Tubulin inhibitor 49 hydrobromide can be used in the research of cervical cancer[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Purity

99.12

Smiles

O=C(C)NC1=CC=C(C2=CSC(NC3=CC=CC(C(F)(F)F)=C3)=N2)C=C1.Br

Molecular Formula

C18H15BrF3N3OS

Molecular Weight

458.30

References & Citations

[1]Mühlethaler T, et al., Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew Chem Int Ed Engl. 2022 Jun 20;61 (25) :e202204052.