Dexmecamylamine
Dexmecamylamine ((+) -Mecamylamine) is the antagonist for nicotinic acetylcholine receptor (nAChR), that antagonises the α3β4/α4β2/α7/α1β1γδ receptor with IC50 of micromolare levels. Dexmecamylamine exhibits anxiolytic and antidepressant-like activities[1].
Product Specifications
CAS Number
[107538-05-6]
Product Name Alternative
(+) -Mecamylamine; TC-5214
UNSPSC
12352005
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CN[C@]1([C@@]2([H])C[C@@](CC2)([H])C1(C)C)C
Molecular Formula
C11H21N
Molecular Weight
167.29
References & Citations
[1]Yu LF, et al., Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. J Med Chem. 2014 Oct 23;57 (20) :8204-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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