Pan-Raf/RTK inhibitor 1
Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf) . Pan-Raf/RTK inhibitor 1 exhibits antiproliferative activities against various cancer cell lines and can be utilized in cancer research[1].
Product Specifications
CAS Number
[1980821-53-1]
UNSPSC
12352005
Target
Raf
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C)C(NC(C2(CC2)C3=NC=NC4=C3NC=N4)=O)=C1)NC5=CC=C(CN6CCOCC6)C(C(F)(F)F)=C5
Molecular Formula
C29H28F3N7O3
Molecular Weight
579.57
References & Citations
[1]Zhang Y, et al. Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance. J Chem Inf Model. 2017 Jun 26;57 (6) :1439-1452.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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