KRO-105714

KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC50=79.2 nM) . KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC50=5.6 nM), inhibits SPC-induced cell migration (IC50=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models[1].

Product Specifications

CAS Number

[1137536-21-0]

UNSPSC

12352005

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=C(NC(C(C)(C)C)=O)N=C(N2CCN(CC2)C3=C(OC)C=CC=C3)S1)C4=CC=CC=C4

Molecular Formula

C26H30N4O3S

Molecular Weight

478.61

References & Citations

[1]Yoon SB, et al., A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis. J Inflamm (Lond) . 2020 May 29;17:20.