PROTAC SMARCA2/4 degrader-37

PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based SMARCA2/4 degrader, with an IC50 of ≤0.1 μM (Pink: SMARCA2/4 lignad (HY-172446) ; Black: CRBN ligand (HY-41547) ; Linker (HY-N2407) ) [1].

Product Specifications

CAS Number

[2688882-69-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Field of Research

Others

Smiles

O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6

Molecular Formula

C37H31ClN8O6

Molecular Weight

719.15

References & Citations

[1]Preparation of bifunctional PROTAC compounds, compositions, and methods for degradation of targeted SMARCA2, SMARCA4 or BRM proteins. Patent WO2021163302 A1.