BCRP-IN-2
BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP, as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone (HY-13502) in H460/MX20 cells with BCRP overexpression[1].
Product Specifications
CAS Number
[2953730-35-1]
UNSPSC
12352005
Target
BCRP
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
[N-]=[N+]=NC1=CC=C(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)C=C1
Molecular Formula
C19H13N7
Molecular Weight
339.35
References & Citations
[1]Chao-Yun Cai, et al. Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability. Biomolecules. 2023 Jan 30;13 (2) :253.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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