Prostaglandin E2 Inhibitor 3

Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM) . Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX) -1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH) . Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice[1].

Product Specifications

CAS Number

[3054217-03-4]

UNSPSC

12352101

Target

PGE synthase

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=C(Br)C=CC=C1)NC2=NN=C(C3=CC=C(C4=CC(O)=CC=C4)C=C3)S2

Molecular Formula

C21H14BrN3O2S

Molecular Weight

452.32

References & Citations

[1]Potenza M, et al. Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors. ACS Med Chem Lett. 2022 Dec 9;14 (1) :26-34.