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M351-0056

M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod -induced psoriatic dermatitis in mouse models[1].

Product Specifications

CAS Number

1189495-81-5

UNSPSC

12352005

Target

VISTA

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(NC1=CC=C(C=C1F)Br)(C2=C(C)SC(C3=CSC(C)=N3)=C2)=O

Molecular Formula

C15H12BrFN2O2S3

Molecular Weight

447.37

References & Citations

[1]Hu X, et al., M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178 (6) :1445-1458.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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