M351-0056
M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod -induced psoriatic dermatitis in mouse models[1].
Product Specifications
CAS Number
1189495-81-5
UNSPSC
12352005
Target
VISTA
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=CC=C(C=C1F)Br)(C2=C(C)SC(C3=CSC(C)=N3)=C2)=O
Molecular Formula
C15H12BrFN2O2S3
Molecular Weight
447.37
References & Citations
[1]Hu X, et al., M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178 (6) :1445-1458.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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