JANEX-1-M

JANEX-1-M is a metabolite of JANEX-1 (HY-15508) . JANEX-1 is a JAK3 specific inhibitor, which can effectively inhibit mast cell degranulation and the release of pro-inflammatory mediators[1].

Product Specifications

CAS Number

[406484-24-0]

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

OC1=CC=C(NC2=C3C=C(OC)C(O)=CC3=NC=N2)C=C1

Molecular Formula

C15H13N3O3

Molecular Weight

283.28

References & Citations

[1]Uckun FM, et al. CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4- (4'-hydroxyphenyl) -amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation. Drug Metab Dispos. 2002 Jan;30 (1) :74-85.