ZK-806450

ZK-806450 is a compound with antiviral activity. ZK-806450 has a high binding potential to the allosteric binding site of the SARS-CoV-2 3CL protease. ZK-806450 can also specifically and stably bind to the GAG site of the dengue virus envelope protein[1][2].

Product Specifications

CAS Number

[247188-27-8]

UNSPSC

12352005

Target

Dengue Virus; SARS-CoV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

N=C(C1=CC=C2C=CC(CN3C4=C(C5=CC=C(C=C53)OC6CCN(CC6)C(C)=N)C=CC=C4)=CC2=C1)N

Molecular Formula

C31H31N5O

Molecular Weight

489.61

References & Citations

[1]Novak J, et al. Proposition of a new allosteric binding site for potential SARS-CoV-2 3CL protease inhibitors by utilizing molecular dynamics simulations and ensemble docking. J Biomol Struct Dyn. 2022;40 (19) :9347-9360.|[2]Chaudhuri D, et al. Repurposing of drugs targeting heparan sulphate binding site of dengue virus envelope protein: an in silico competitive binding study. Mol Divers. 2025 Feb;29 (1) :87-101.