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Calcium Channel antagonist 6

Calcium Channel antagonist 6 (Compound 328) is a highly selective antagonist of voltage-gated calcium channel CaV2.2 with an IC50 value of 0.37 μM. Calcium Channel antagonist 6 inhibits of neuron depolarization-induced Ca2+ influx. Calcium Channel antagonist 6 is promising for research of neuropathic pain[1].

Product Specifications

CAS Number

[687568-35-0]

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N1CCN(CC1)C(C2=C(C)C3=C(C=CC(S(=O)(N(CC)CC)=O)=C3)O2)=O)OCC

Molecular Formula

C21H29N3O6S

Molecular Weight

451.54

References & Citations

[1]Andreas P. Termin, et al. Heterocyclic derivatives for modulation of calcium channels. WO2006010008A1. 2006-01-26.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

N-type calcium channel

Curated Selection

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