IHCH-7086

IHCH-7086 is a β-arrestin-biased 5-HT2A serotonin receptor agonist (Ki: 12.59 nM) . IHCH-7086 recruits β-arrestin through activation of 5-HT2A receptors, thereby removing hallucinogenic activity. IHCH-7086 improves depression-like behavior in mice without hallucinogenic effects[1][2].

Product Specifications

CAS Number

[2957888-70-7]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1C2=C3C([C@@]4([H])[C@@](CCN(C4)CCCC5=C(C=CC=C5)OC)([H])N3CC1)=CC=C2

Molecular Formula

C24H31N3O

Molecular Weight

377.52

References & Citations

[1]Yin YN, Gao TM. Non-hallucinogenic Psychedelic Analog Design: A Promising Direction for Depression Treatment. Neurosci Bull. 2023 Jan;39 (1) :170-172.|[2]Cao D, et al. Structure-based discovery of nonhallucinogenic psychedelic analogs. Science. 2022 Jan 28;375 (6579) :403-411.