1-Benzyl-APDC
1-Benzyl-APDC acts as an agonist for mGluR6, with an EC50 of 20 μM in CHO cells. 1-Benzyl-APDC is a weak antagonist of mGluR2, with an IC50 of 200 μM[1].
Product Specifications
CAS Number
171336-76-8
UNSPSC
12352005
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
OC([C@@H](C[C@@](N)(C1)C(O)=O)N1CC2=CC=CC=C2)=O
Molecular Formula
C13H16N2O4
Molecular Weight
264.28
References & Citations
[1]J K Mukhopadhyaya, et al. Synthesis of N (1) -substituted analogues of (2R,4R) -4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1919-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR6
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