2- (Cyclohexylmethyl) -plumbagin

2- (Cyclohexylmethyl) -plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497) . Under nutrient-deprived conditions, 2- (Cyclohexylmethyl) -plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2- (Cyclohexylmethyl) -plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2- (Cyclohexylmethyl) -plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model[1].