TRPML modulator 1

TRPML modulator 1 (compound A12) is a TRPML modulator that promotes autophagy. TRPML modulator 1 AC50 in the TFEB test is less than 2 mM[1].

[2171065-77-1]

12352005

Autophagy; TRP Channel

Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling

Cancer; Neurological Disease; Cardiovascular Disease

O=S(NC1=C(N2CCN(CC2)C3=CC=C(C=C3F)Cl)C=CC=C1)(C4=CC=C(S(=O)(N(C)C)=O)C=C4)=O

C24H26ClFN4O4S2

553.07

[1]Jorge Garcia FORTANET, et al. Trpml modulators. WO. WO2021127337A1. 2020-12-18.

Room temperature

Reference compound1

No Development Reported

Curated Selection

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