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SGLT1/2-IN-8

SGLT1/2-IN-8 (compound 8) is a potent and orally active SGLT1/2 dual inhibitor with IC50 values of 4 nM and 1 nM, respectively. SGLT1/2-IN-8 exhibits anti-hyperglycemic effects and can be utilized in relevant research[1].

Product Specifications

CAS Number

2206679-16-3

UNSPSC

12352005

Target

SGLT

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

OC1=CC(C)=C(CC2=CC=C(CC3)C3=C2)C=C1[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO

Molecular Formula

C22H26O6

Molecular Weight

386.44

References & Citations

[1]Kuo GH, et al. Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors. Bioorg Med Chem Lett. 2018 Apr 15;28 (7) :1182-1187.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SGLT1; SGLT2

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