Yakuchinone B
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC50 value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis[1].
Product Specifications
CAS Number
81840-57-5
UNSPSC
12352211
Target
Acyltransferase
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
98.86
Smiles
O=C(CCCCC1=CC=CC=C1)/C=C/C2=CC(OC)=C(C=C2)O
Molecular Formula
C20H22O3
Molecular Weight
310.39
References & Citations
[1]Ohishi K, et al. Structure-activity relationships of N- (3,5-dimethoxy-4-n-octyloxycinnamoyl) -N'- (3,4-dimethylphenyl) piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase. Chem Pharm Bull (Tokyo) . 2001 Jul;49 (7) :830-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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