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Yakuchinone B

Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC50 value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis[1].

Product Specifications

CAS Number

81840-57-5

UNSPSC

12352211

Target

Acyltransferase

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.86

Smiles

O=C(CCCCC1=CC=CC=C1)/C=C/C2=CC(OC)=C(C=C2)O

Molecular Formula

C20H22O3

Molecular Weight

310.39

References & Citations

[1]Ohishi K, et al. Structure-activity relationships of N- (3,5-dimethoxy-4-n-octyloxycinnamoyl) -N'- (3,4-dimethylphenyl) piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase. Chem Pharm Bull (Tokyo) . 2001 Jul;49 (7) :830-9.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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