PKZ18
PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance[1][2].
Product Specifications
CAS Number
849658-87-3
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC(S1)=C(C2=CC=C(C=C2)C(C)C)N=C1NC([C@@H]3[C@@H]([C@]4([H])C[C@@]3([H])CC4)C(O)=O)=O
Molecular Formula
C22H26N2O3S
Molecular Weight
398.52
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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