L-657926
L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-) -9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+) -9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
Product Specifications
CAS Number
113243-00-8
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
FC1=CC=C(N(C2=C3CCC[C@H]2CC(O)=O)CC4=CC=C(C=C4)Cl)C3=C1
Molecular Formula
C21H19ClFNO2
Molecular Weight
371.83
References & Citations
[1]Folger WH, Halushka PV, Wilcox CS, Guzman NJ. Characterization of rat glomerular thromboxane A2 receptors: comparison to rat platelets. Eur J Pharmacol. 1992 Sep 1;227 (1) :71-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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