PKN3-IN-1

PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1].

Product Specifications

CAS Number

[2361545-75-5]

UNSPSC

12352005

Target

PI3K

Related Pathways

PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Purity

98.97

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)

Smiles

IC1=CC2=NC=CC(NC3=CC(OC)=C(C(OC)=C3)OC)=C2C=C1

Molecular Formula

C18H17IN2O3

Molecular Weight

436.24

References & Citations

[1]Asquith CRM, et al. Identification of 4-Anilinoquin (az) oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. ChemMedChem. 2022 Jun 20;17 (12) :e202200161.|[2]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018 Jan 8;13 (1) :48-66.