VVD 065
VVD 065 is an orally active Keap1-Cul3 Ligands for E3 LigaseMolecular Glues. VVD 065 can activate KEAP1, thereby promoting the degradation of NRF2. VVD 065 can inhibit tumor growth in a non-small cell lung cancer/esophageal squamous cell carcinoma xenograft model. VVD 065 can be used for research on cancers such as non-small cell lung cancer and esophageal squamous cell carcinoma[1].
Product Specifications
CAS Number
3034876-85-9
UNSPSC
12352101
Target
Keap1-Nrf2; Ligands for E3 Ligase; Molecular Glues
Related Pathways
NF-κB; PROTAC
Field of Research
Cancer
Smiles
C=CC(N1[C@H](C2=CC(C3=NC=NC(N)=N3)=CC(Cl)=C2)COCC1)=O
Molecular Formula
C16H16ClN5O2
Molecular Weight
345.78
References & Citations
[1]Nil Roy, et al. Discovery of VVD-065, a first-in-class allosteric molecular glue of the Keap1-Cul3 E3-ligase complex for the treatment of NRF2-activated cancers. Mol Cancer Ther 1 December 2023; 22 (12_Supplement) : PR011.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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