VVD 065

VVD 065 is an orally active Keap1-Cul3 Ligands for E3 LigaseMolecular Glues. VVD 065 can activate KEAP1, thereby promoting the degradation of NRF2. VVD 065 can inhibit tumor growth in a non-small cell lung cancer/esophageal squamous cell carcinoma xenograft model. VVD 065 can be used for research on cancers such as non-small cell lung cancer and esophageal squamous cell carcinoma[1].

Product Specifications

CAS Number

[3034876-85-9]

UNSPSC

12352101

Target

Keap1-Nrf2; Ligands for E3 Ligase; Molecular Glues

Related Pathways

NF-κB; PROTAC

Field of Research

Cancer

Smiles

C=CC(N1[C@H](C2=CC(C3=NC=NC(N)=N3)=CC(Cl)=C2)COCC1)=O

Molecular Formula

C16H16ClN5O2

Molecular Weight

345.78

References & Citations

[1]Nil Roy, et al. Discovery of VVD-065, a first-in-class allosteric molecular glue of the Keap1-Cul3 E3-ligase complex for the treatment of NRF2-activated cancers. Mol Cancer Ther 1 December 2023; 22 (12_Supplement) : PR011.