D-F07
D-F07 is a prodrug with an aldehyde shielding group and an IRE-1 inhibitor that induces Apoptosis. D-F07 has antitumor activity[1][2].
Product Specifications
CAS Number
2361297-58-5
UNSPSC
12352005
Target
Apoptosis; IRE1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1OC2=C(C3=C1CN(CC3)C)C=C(C(O)=C2C4OCCCO4)OC
Molecular Formula
C18H21NO6
Molecular Weight
347.36
References & Citations
[1]Shao A, et al. Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy. Mol Cancer Ther. 2020 Dec;19 (12) :2432-2444.|[2]Shao A, et al. IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy. Mol Pharm. 2022 Apr 4;19 (4) :1059-1067.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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