CEE321
CEE321 is a potent pan-JAK inhibitor with an IC50 value of 54 nM. CEE321 potently inhibits biomarkers associated with atopic dermatitis[1].
Product Specifications
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CN=C(NC2=CC=CC(C)=N2)C=C1NC3=C(Cl)C=CC=C3)N
Molecular Formula
C18H16ClN5O
Molecular Weight
353.81
References & Citations
[1]Thoma G, et al. Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. J Med Chem. 2023 Feb 9;66 (3) :2161-2168.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169758/
Scientific Category
Reference compound1
Clinical Information
Phase 1
CAS Number
[2098545-89-0]
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