Fluralaner-d2

Fluralaner-d2 (A1443-d2) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

Product Specifications

Product Name Alternative

A1443-d2; AH252723-d2

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Parasite

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(C1=CC=C(C=C1C)C2=NOC(C3=CC(Cl)=CC(Cl)=C3)(C2)C(F)(F)F)NCC(NC([2H])([2H])C(F)(F)F)=O

Molecular Formula

C22H15D2Cl2F6N3O3

Molecular Weight

558.30

References & Citations

[2]Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275.|[3]Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1 (-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.