Aurora A inhibitor 4

Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A, with the GI50 of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively[1].

Product Specifications

CAS Number

[371224-09-8]

UNSPSC

12352005

Target

Aurora Kinase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1N=C(NC(C1)C2=CC=C(C=C2)OC)NC3=NC(C)=C4C=C(OCC)C=CC4=N3

Molecular Formula

C22H23N5O3

Molecular Weight

405.45

References & Citations

[1]Mohammad Neaz Morshed, et al. Computational approach to the identification of novel Aurora-A inhibitors. Bioorg Med Chem. 2011 Jan 15;19 (2) :907-16.