NA-17
NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death[1].
Product Specifications
CAS Number
[1708948-28-0]
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C1C2=CC=CC3=C2C(C(N1CCC4=CC=C5OCOC5=C4)=O)=CC=C3NCCCN(C)C
Molecular Formula
C26H27N3O4
Molecular Weight
445.51
References & Citations
[1]Guohai Zhang, et al. A Novel Naphthalimide Compound restores p53 function in Non–Small–Cell by Reorganizing the Bak–Bcl-xl Complex and Triggering Transcriptiona regulation. JBC. December 14, 2015.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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