NA-17

NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death[1].

Product Specifications

CAS Number

[1708948-28-0]

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C1C2=CC=CC3=C2C(C(N1CCC4=CC=C5OCOC5=C4)=O)=CC=C3NCCCN(C)C

Molecular Formula

C26H27N3O4

Molecular Weight

445.51

References & Citations

[1]Guohai Zhang, et al. A Novel Naphthalimide Compound restores p53 function in Non–Small–Cell by Reorganizing the Bak–Bcl-xl Complex and Triggering Transcriptiona regulation. JBC. December 14, 2015.