NPC26
NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29) . NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway[1].
Product Specifications
CAS Number
[864860-32-2]
UNSPSC
12352100
Target
AMPK; Reactive Oxygen Species (ROS)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
98.0
Smiles
O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC3=C1CC(C)(C)NC3(C)C)OCC
Molecular Formula
C19H23N3O5S2
Molecular Weight
437.53
References & Citations
[1]Zhen Zhao, et al. NPC-26 kills human colorectal cancer cells via activating AMPK signaling. Oncotarget. 2017 Feb 17;8 (11) :18312–18321.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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