NPC26
NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29) . NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway[1].
Product Specifications
CAS Number
[864860-32-2]
UNSPSC
12352100
Target
AMPK; Reactive Oxygen Species (ROS)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
98.0
Smiles
O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC3=C1CC(C)(C)NC3(C)C)OCC
Molecular Formula
C19H23N3O5S2
Molecular Weight
437.53
References & Citations
[1]Zhen Zhao, et al. NPC-26 kills human colorectal cancer cells via activating AMPK signaling. Oncotarget. 2017 Feb 17;8 (11) :18312–18321.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Rhizobium leguminosarum bv. viciae Protein MraZ (mraZ)
Recombinant Rhizobium leguminosarum bv. viciae Protein MraZ (mraZ)
Recombinant Rhizobium leguminosarum bv. viciae Protein MraZ (mraZ)
Recombinant Rhizobium leguminosarum bv. viciae Protein MraZ (mraZ)
Recombinant Rhizobium leguminosarum bv. viciae Protein MraZ (mraZ)