DBMB

DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) . DBMB can be utilized in research on inflammatory diseases[1].

Product Specifications

CAS Number

[314027-66-2]

UNSPSC

12352005

Target

NF-κB; NO Synthase; Prostaglandin Receptor; Syk

Related Pathways

GPCR/G Protein; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

COC1=C(C=CC=C1)CC(C2=NC3=C(N2)C=CC=C3)CC4=NC5=C(N4)C=CC=C5

Molecular Formula

C24H22N4O

Molecular Weight

382.46

References & Citations

[1]Kim E, et al. 1- (2, 3-dibenzimidazol-2-ylpropyl) -2-methoxybenzene is a Syk inhibitor with anti-inflammatory properties[J]. Molecules, 2016, 21 (4) : 508.