Serotonin (maleate)

Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM [1] [2].

Product Specifications

CAS Number

[18525-25-2]

Product Name Alternative

5-Hydroxytryptamine (maleate) ; 5-HT (maleate)

UNSPSC

12352005

Target

5-HT Receptor; COMT

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

NCCC(C1=C2)=CNC1=CC=C2O.OC(/C=C\C(O)=O)=O

Molecular Formula

C14H16N2O5

Molecular Weight

292.29

References & Citations

[1]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.|[2]Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8 (8) :e72774.