4-Hydroxytamoxifen (Standard)
4-Hydroxytamoxifen (Standard) is the analytical standard of 4-Hydroxytamoxifen. This product is intended for research and analytical applications. 4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen in vivo and can be used to induce gene knockout in transgenic mice expressing CreER[1][2][3][4].
Product Specifications
CAS Number
68047-06-3
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Reference Standards
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3
Molecular Formula
C26H29NO2
Molecular Weight
387.52
References & Citations
[1]Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75 (2) :305-16.|[2]Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11 (5) :316-8.|[3]Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87 (6) :1436-43.|[4]Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Phase 2
Available Sizes
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