AP-1
AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK). AP-1 is composed of PROTAC target protein ligand CS-1243648 (red part), E3 ligase ligand Pomalidomide (HY-10984) (blue part) and PROTAC Linker 2- (Tert-Butoxy) -2-oxoacetic acid (HY-W687662) (black part).
Product Specifications
CAS Number
3027918-96-0
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
97.8
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(CC4)C5=CC=C(C(OC)=C5)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl)=O)=CC=C3)=O)=O
Molecular Formula
C39H40ClN9O8S
Molecular Weight
830.31
References & Citations
[1]Lidong Gong, et al. Discovery of a miniaturized PROTAC with potent activity and high selectivity. Bioorg Chem. 2023 Jul:136:106556.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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