Lipid C2
Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3+CD8+ central and CD3+CD8+ effector memory T cells and decrease the percentage of CD3+ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model[1].
Product Specifications
CAS Number
3003022-09-8
UNSPSC
12352005
Target
Liposome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Smiles
O=C(CCN1CCN(CC1)CCC(NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O
Molecular Formula
C70H142N6O6
Molecular Weight
1163.91
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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