PAMAM dendrimer G0.5 carboxylate (sodium)
PAMAM Dendrimer G0.5 Carboxylate sodium is a polyamidoamine (PAMAM) dendrimer with carboxylate termini. PAMAM Dendrimer G0.5 Carboxylate sodium conjugated with DACHPt is cytotoxic to A2780 ovarian cancer cells, MCF-7 breast cancer cells, Caco-2 colon cancer cells and BJ fibroblasts with IC50 values of 0.03, 1.6, 0.18 and 3 µM, respectively[1].
Product Specifications
CAS Number
[339334-01-9]
UNSPSC
12352211
Target
Biochemical Assay Reagents
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCN(CCC(O[Na])=O)CCNC(CCN(CCN(CCC(NCCN(CCC(O[Na])=O)CCC(O[Na])=O)=O)CCC(NCCN(CCC(O[Na])=O)CCC(O[Na])=O)=O)CCC(NCCN(CCC(O[Na])=O)CCC(O[Na])=O)=O)=O)O[Na]
Molecular Formula
C46H72N10Na8O20
Molecular Weight
1269.04
References & Citations
[1]Camacho C, et al. Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs. Molecules. 2021 May 14;26 (10) :2924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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