Cannabidiolic acid methyl ester
Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects[1][2][3].
Product Specifications
CAS Number
55658-71-4
Product Name Alternative
HU-580
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC([C@H]1[C@H](C2=C(C(C(OC)=O)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
Molecular Formula
C23H32O4
Molecular Weight
372.50
References & Citations
[1]Pertwee RG, et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 2018 Jan;175 (1) :100-112.|[2]Zhu YF, et al. An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol. 2020 Jun;177 (12) :2712-2725.|[3]Murillo-Rodríguez E, et al.Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res. 2021 Jul 12;3 (1) :31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3
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