GSK4418959 (enantiomer)
GSK4418959 enantiomer is an enantiomer of GSK4418959. GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer[1].
Product Specifications
CAS Number
3064599-37-4
Product Name Alternative
IDE275 (enantiomer)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(N(C(C)=N2)C)C2=C1)(N(C3=CC=C([C@@H]4CCC[C@@H]([C@H]4C(O)=O)C(NC5=C(F)C=C(C(F)(F)F)C=C5)=O)C=C3)C)=O
Molecular Formula
C31H30F4N4O5S
Molecular Weight
646.65
References & Citations
[1]Joshua P. Taygerly, et al. Abstract 5750: Discovery of GSK4418959 (IDE275) : A novel, non-covalent, reversible Werner Helicase inhibitor and a new potential therapeutic for the treatment of MSI-H cancers. Cancer Res (2025) 85 (8_Supplement_1) :5750.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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