GSK4418959 (enantiomer)

GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422) . GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer[1].

Product Specifications

CAS Number

[3064599-37-4]

Product Name Alternative

IDE275 (enantiomer)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Concentration

10mM

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(N(C(C)=N2)C)C2=C1)(N(C3=CC=C([C@@H]4CCC[C@@H]([C@H]4C(O)=O)C(NC5=C(F)C=C(C(F)(F)F)C=C5)=O)C=C3)C)=O

Molecular Formula

C31H30F4N4O5S

Molecular Weight

646.65

References & Citations

[1]Joshua P. Taygerly, et al. Abstract 5750: Discovery of GSK4418959 (IDE275) : A novel, non-covalent, reversible Werner Helicase inhibitor and a new potential therapeutic for the treatment of MSI-H cancers. Cancer Res (2025) 85 (8_Supplement_1) :5750.