PDE1-IN-9 (hydrochloride)
PDE1-IN-9 (Compound 7a) hydrochloride is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 hydrochloride reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS) . PDE1-IN-9 hydrochloride exhibits good metabolic stability in rat liver microsomes[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NO Synthase; Phosphodiesterase (PDE) ; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Purity
98.74
Smiles
N#CC1=C(C2CCCC2)C3=C(C=C(NCC4CCOCC4)C=C3)N(CC5=CC=CC=C5)C1=O.Cl
Molecular Formula
C28H32ClN3O2
Molecular Weight
478.03
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; PDE1
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